Microdermabrasion is a minimally invasive mechanical exfoliation procedure for superficial skin resurfacing. The depth of resurfacing achieved with Microdermabrasion is conservatively in the middle of this spectrum. Although thi type of exfoliation can vary from superficial thinning of the stratum corneum to penetration into the upper papillary dermis, the target depth for most procedures is removal of the stratum corneum.

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Exfoliation treatments are based on the principles of wound healing. By wounding and removing the uppermost layers of the skin in a controlled manner, cell renewal is stimulated with regeneration of a healthier epidermis and dermis. Histological evaluation of facial skin after repeated microdermabrasion treatments demonstrates a reparative wound-healing process with regeneration of a compacted stratum corneum and a smoother epidermis. 

Skin hydration increases with improved epidermal barrier function, and fibroblast stimulation increases dermal thickness through production of new collagen and elastin.